Finally, the xid/xid mice failed to produce antiDNA in response to multiple injections of the polyclonal activator, bacterial lipopolysaccharide (LPS), or the polyclonal activator, polyribose inosinic acid.
The xid/xid mice failed to produce anti-ssDNA following immunization with ssDNA complexed to a protein carrier in fluid form or even emulsified in adjuvant. The effect of xid/xid upon (NZB X NZW)F1 mice was further investigated by assessing responses to immunization and polyclonal B cell activation in vivo. Similar results were also obtained with (NZW X NZB)F1 xid/xid mice compared with (NZW X NZB)F1 xid/+ mice. In these studies, xid/xid mice failed to develop the characteristic signs of autoimmunity, whereas the controls did. In these and in additional studies, mice were housed in the same cages and identified by ear tagging so as to avoid possible environmental variations from cage to cage. xid/xid (and therefore "defective") or (NZB X NZW)F1. xid/Y males such that the resulting offspring were either (NZB X NZW)F1. To control for unknown genetic factors, studies were performed with littermates that were derived by mating NZB. They also failed to develop fatal renal disease as measured by proteinuria, glomerular histology, glomerular immunofluorescence, and survival. xid/xid females failed to develop antibodies to single-stranded or native DNA. These mice were different from (NZB X NZW)F1 mice in having the X chromosome-linked immune deficiency gene, xid, in homozygous form.
By a series of matings, congenic (NZB X NZW)F1. We want to keep a responsive website so do not run any scraping scripts or we will ban your IP-address.F1 hybrid offspring of New Zealand Black mothers and New Zealand White fathers female mice develop antibodies to single-stranded (ss) and native DNA, immune complex glomerulonephritis, massive proteinuria, and premature death with renal failure. Commercial use, in any shape or form, is strictly prohibited. You may use this site only for your own personal use and at your own risk.
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